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Emmy winner Kelsey Grammer was born on St. Thomas in the United States Virgin Islands, and was raised by his mother and grandfather, first in New Jersey, then in Florida. By age eleven, Grammer was drawn to the works of Shakespeare, which fostered his new-found love of the English language. He first acted in a high school production of The Little Foxes, and with the encouragement of his English and drama teachers, decided to pursue acting as a career. After two years at the Julliard School, he accepted by the Old Globe Theatre in San Diego, where he spent three years performing in classic works by Shakespeare and George Bernard Shaw.

He later performed in regional theaters across the United States before appearing in Off-Broadway productions of Plenty, Sunday in the Park with George, A Month in the Country, and the Obie Award winning Quartermaine's Terms.

Among his television credits are roles on the daytime dramas Another World, One Life to Live and Guiding Light. He joined Cheers in 1984, and became the first actor in television history to receive Emmy nominations for his performance as a character he created on three seperate series. He received two Emmy nominations for his portrayal of Dr. Frasier Crane on Cheers; his guest appearance as the vacationing Frasier Crane on NBC's Wings in 1992 earned him another Emmy nomination as Outstanding Guest Actor in a Comedy Series; and he received an Emmy as Best Actor in a New Comedy Series in the debut season of Frasier, in which he stars in the title role. Among Grammer's other television credits are appearances on the series Star Trek: The Next Generation, Kate and Allie and The Tracy Ullman Show, plus the miniseries Kennedy and Washington, as well as the telefilms Dance 'til Dawn, The Innocent and Beyond Suspicion. He also lends his voice to the animated character, Sideshow Bob, on The Simpsons.

His first film work came as the co-star of the independent feature Galaxies are Colliding. He also starred in Down Periscope, Pop Up, and The Real Howard Spitz, and lending his voice talent to such projects as Anastasia and Toy Story 2. In 2006 Grammer appeared in X-Men: The Last Stand.