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Adrian Monk (Emmy-winner Tony Shalhoub) is a highly gifted detective whose career is jeopardized by his overwhelming fear of germs, crowds, small places, and almost everything else..
Monk's disorder was triggered by the murder of his beloved wife, Trudy.
Ordered to take a leave of absence from the police department, Monk hires a nurse who helps him try to get reinstated on the force, and in the process, becomes an unlikely "Dr. Watson" to his "Sherlock Holmes."
When the police department find themselves unable to crack a high-profile case, they have no choice but to bring back the only man for the job...phobias and all.